After receiving his PhD from the University of Edinburgh , Dr Dockrell worked for five years as a post-doctoral research fellow and for a further 2 years as an honorary lecturer with Professor Bruce Hendry in the Department of Renal Medicine at King’s College, London. He joined the S W Thames Institute for Renal Research as a Lecturer in December 2002.

Publications

Dr Dockrell has written over 20 full publications, a selection of which are listed below:

Motazed R,Colville-Nash P, Kwan JTC, Dockrell MEC (2008) BMP-7 and Proximal Epithelial Cells: activation of multiple signaling pathways reveals a novel anti-fibrotic mechanism Pharm Res. 2008 Feb 21; [Epub ahead of print]

Diwakar R, de C Pearson A, Colville-Nash P, Baines DL, Dockrell MEC (2008 ) Role played by Disabled 2 in albumin-induced MAP kinase signalling Feb 15; 366( 3): 675-80. Epub 2007 Dec 10.

Niculescu-Duvaz I, Phanish MK, Colville-Nash P, Dockrell ME. (2007) The TGFbeta1-induced fibronectin in human renal proximal tubular epithelial cells is p38 MAP kinase dependent and Smad independent. Nephron Exp Nephrol.;105(4):e108-16. Epub 2007 Mar 7.

Diwakar R, de C Pearson A, Colville-Nash P, Brunskill NJ, Dockrell MEC (2007) The Role Played by Endocytosis in Albumin Induced Secretion of TGFβ-1 by Proximal Tubular Epithelial Cells Am J Physiol Renal Physiol. 2007 May;292(5):F1464-70. Epub Jan 9.

Niculescu-Duvaz I, D'Mello L, Maan Z, Barron JL, Newman DJ, Dockrell MEC, Kwan JTC (2006) Development of an outpatient finger-prick glomerular filtration rate procedure suitable for epidemiological studies. Kidney Int 69(7):1272-5

Phanish ML, Wahab NA, Colville-Nash P, Hendry BM, Dockrell MEC (2005) The differential role of Smad2 and Smad3 in regulation of pro-fibrotic TGF-beta1 responses in human proximal tubule epithelial cells. Biochem J. 393: 601-607

Phanish MK, Wahab NA Hendry BM , Dockrell MEC (2005) TGF- b1-Induced Connective Tisssue Growth Factor (CCN2) Expression in Human Renal Proximal Tubule Epithelial Cells Requires Ras/MEK/ERK and Smad Signalling. Nephron Exp Nephrol. 100(4):e156-65

Research Activities

Ongoing research topics include

TGF-beta signalling in non-malignant renal epithelial cells

The MAP kinase pathways in fibrosis signalling

The role of Id proteins in the regulation of renal epithelial cell phenotype

The cellular actions of BMP-7 in the adult kidney

Proteinuria mediated fibrosis – the role of albumin signalling

Obtained grants from

High Blood Pressure Foundation

British Heart Foundation

The South West Thames Kidney Fund

Epsom & St Helier University Hospitals NHS Trust Research and Development

Genzyme Research Initiative Program (GRIP)